Abstract
Background Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Methods Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. Results The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9 ± 12.6% to 83.8 ± 17.7% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (p = 0.03), forced expiratory volume in one second (FEV1) from 75.2 ± 18.3% to 83.3 ± 19.0% (Conclusion The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.
Highlights
Myasthenia gravis (MG) is an immune-mediated neuromuscular junction disorder characterized by fluctuating muscle weakness and easy fatigability
There was no significant difference between the respiratory muscle training (RMT) group and the disease control group in terms of age, sex, body weight, body high, duration of disease, cardiovascular autonomic function, pulmonary function parameters, or MGFA classification
The present study examined the RMT effects on pulmonary function, MG outcomes, and fatigue in MG patients
Summary
Myasthenia gravis (MG) is an immune-mediated neuromuscular junction disorder characterized by fluctuating muscle weakness and easy fatigability. Class I is defined as patients with any ocular muscle weakness and all other muscle strength as normal. Classes II to IV are defined as patients with mild to severe muscle weakness affecting other than ocular muscles, respectively. The effect of RMT may be performed safely and effectively in mild to moderate MG patients (classes II and III) with impairment of respiratory function [5, 6]. Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG.
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