Abstract
A close association has been established between onset of infection with an ECHO virus (JV-1) and the onset of a mild clinical respiratory illness in six infants 5 months to 14 months of age. The illnesses were characterized by coryza, pharyngitis, and fever of short duration. Other manifestations included abnormal stools, erythema of the ear drums, and mild conjunctival congestion. Examination of paired acute and convalescent sera from the infants demonstrated a rise in titer of both neutralizing and complement-fixing antibodies against the prototype JV-1 virus. Conversely, tests of sera taken from the same time period of the illnesses did not, with one exception, reveal rising antibodies against adenoviruses, Coxsackie A viruses, ECHO type 8 virus, and influenza A, B, and C viruses.
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