Abstract
AbstractAim:This study aims to compare the gating signals of patients with lung cancer recorded during the planning computed tomography scan with the ones recorded during treatment fractions. The results provide insights into how representative the respiratory signals from the planning scan are for radiation dose partitioning.Materials and methods:The amplitude and frequency of the respiratory signals of 29 patients with lung carcinoma were analysed and compared with the amplitude and frequency of those recorded during their planning scans. Moreover, a cross-correlation analysis was performed between the difference between the planning scan and fractions and features from the planning scan.Results:Two patients showed significantly different amplitude and frequency during treatment fractions compared to those from the planning scan. These patients showed low variances in frequency and amplitude during the different fractions. The difference between planning scan and fractions is correlated with the variances within the planning scan.Findings:Respiratory signals can differ between the planning scan and the fractions. In this case, a new planning scan may be beneficial. The respiratory signals from the planning scan may be predictive of whether the planning scan will be representative and usable as a control measure during radiotherapy fractions.
Highlights
Lung cancer is one of the most diagnosed cancers among the Dutch population
The present study aims to investigate whether the planning scan of patients with lung cancer is representative during the radiotherapy fractions
A method to analyse respiratory signals for respiratory gating was developed to investigate whether the planning scan is representative during the treatment fractions of patients with lung cancer
Summary
In 2020, 13,910 new patients with lung cancer were reported.[1] Currently, the treatment of more than 50% of these patients involves radiation therapy. This primarily curative treatment can be combined with other forms of treatment such as surgery and chemotherapy.[2] The benefits of radiation therapy are a reduced likelihood of recurrence and a better chance of survival.[3,4,5,6]. This modification amplifies the risk of normal tissue toxicity
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