RESPIRATORY DISTRESS SYNDROME IN ACUTE PANCREATITIS (EXPERIMENTAL STUDY)

Abstract

Aim. To assess the role of lipid metabolism disorders and coagulation-lytic changes of lung tissue structures in the pathogenesis of respiratory distress syndrome in acute pancreatitis. Material and Methods. The study is based on experiments on adult mongrel dogs. The model is acute pancreatitis by V.M. Buyanov et al. (1989). In target dates blood sample, bronchoalveolar lavage and biopsy of lung tissue were analyzed. We investigated free-radical processes, phospholipase and protease activity, qualitative and quantitative composition of lipids, coagulation-lytic state of tissues, functional state of surfactant and transcapillary fluid exchange. Results. It was found that acute pancreatitis is associated with significant disorders of transcapillary exchange of fluid in lungs, function and composition of surfactant, that led to respiratory impairment. Lipid metabolism disorders and coagulation-lytic changes in lungs are main pathogenetic mechanisms of respiratory distress syndrome. Metabolic changes in lungs are associated with endogenous intoxication. Conclusion. Pulmonary lipid metabolism changes and tissue coagulation-lytic system modification occur in acute pancreatitis due to endogenous intoxication, increased phospholipase and proteolytic activity, intensification of lipid peroxidation. These disorders leads to violation of transcapillary fluid exchange, functional state of surfactant followed by respiratory distress syndrome development.excessive intensification of lipid peroxidation, increased activity of phospholipases and proteases.