RESPIRATORY CHANGES IN OFFSPRING OF HIGH FAT DIET FED DAMS

Abstract

Several studies have demonstrated that early life over‐nutrition, such as maternal obesity, is associated with increased risk of cardio‐metabolic diseases. In the present study respiratory changes were investigated in offspring of high fat diet (HFD) fed dams. Adult female Holtzman rats (250 g) were fed with standard diet (SD) or HFD during 6 weeks before, during gestation and lactation. After weaning, male offspring of SD dams (O‐SD, n = 7–12) or HFD dams (O‐HFD, n = 7–12) were fed with SD. The results showed that O‐HFD (P28–32) presented an increase in retroperitoneal adipose tissue (0.15 ± 0.01, vs O‐SD: 0.08 ± 0.01 g/100 g of bw, p < 0.05), a higher plasma triglycerides levels (141 ± 11, vs. O‐SD 49 ± 10 mg/dl, p < 0.05) and insulin intolerance (1.28 ± 0.30, vs O‐SD: 2.25 ± 0.15 % of glucose disappearance/min, p <0.05). At P40, baseline ventilation was higher in the O‐HFD group (1.200 ± 48, vs O‐SD: 924 ± 58, ml.kg‐1.min‐1, p <0.05) due to an increase in tidal volume (9.12 ± 0.29, vs O‐SD: 7.43 ± 0.47, ml.kg‐1, p <0.05). An increased response to hypoxia was also observed in O‐HFD (1.634 ± 80, vs O‐SD: 1.325 ± 50 mL.kg‐1.min‐1, p <0.05). The results demonstrated that young offspring of obese dams have metabolic dysfunctions. The data also demonstrated that these offspring have baseline ventilatory changes as well as an exaggerated response to peripheral chemoreflex activation.Support or Funding InformationFAPESP (2015/234677), CNPq (425586/2016‐2).This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.