Abstract

As an approach to the study of the mechanism of eczematous sensitization, a Warburg study was undertaken of the respiratory activity of skin and reticuloendothelial tissues of guinea pigs sensitized with 2,4-dinitrochlorobenzene (DNCB). It was thought that tissues of such sensitized animals might exhibit changes in QQ2 (microliters of oxygen taken up by 1 mg. dry tissue per hour) on introducing the antigen into the system. However, such behavior was not noted. In addition, no significant changes were found in nucleic acid levels of skin (DNA) and spleen (DNA and RNA) from sensitized animals as compared with the control values.

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