Abstract
A resonance light scattering (RLS) method has been developed using a uranyl (UO22+) specific DNAzyme and gold nanoparticles (AuNPs). In this strategy, the cleavage of the substrate strand (SDNA) of DNAzyme results in releasing a shorter duplex in the presence of UO22+, leading to the aggregation of AuNPs and the increase of RLS intensity. The response signals linearly correlated with the concentration of UO22+ over the range of 1.36×10−8–1.50×10−7molL−1. The limit of detection (LOD) is 4.09×10−9molL−1. The method has excellent selectivity and higher sensitivity. It could provide a promising potential for the detection of metal ions, and be benefit to extend the application of RLS method.
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