Resolved of Respiratory Failure Following the Use Pulse-Doses of Methylprednisolone in a Cytokine Storm Related to 2019 novel coronavirus

Hamid Khederlou,Elham Nezhadseifi,Abdolrahman Rostamian,Hourvash Ebrahimi-Louyeh

doi:10.22631/rr.2020.69997.1102

Hamid Khederlou, Elham Nezhadseifi + Show 2 more

Open Access

https://doi.org/10.22631/rr.2020.69997.1102

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Abstract

Since mid-December of 2019, an outbreak of pneumonia has been spread from Wuhan City, Hubei province, China, as a viralpneumonia. After virus identification and isolation, the pathogen for this pneumonia was originally called 2019 novelcoronavirus (2019-nCoV). 2019-nCoV has been associated with progressive cytokine storm leading to a hyper-inflammatorystate that this state associated with respiratory failure. We hereby reported a known case of Rheumatoid arthritis, Hypertensionand Coronary artery bypass graft that confirmed 2019-nCoV and he was associated with progressive cytokine storm leading torespiratory failure. After corticosteroid administration, respiratory failure and extremely high levels of IL6 respondeddramatically to pulse-doses of Methylprednisolone. We concluded that pulse-doses of Corticosteroids can be effective incontrolling and relieving cytokine storms and related respiratory failure.

Highlights

Coronaviruses are enveloped RNA viruses of the family coronaviridae and broadly distributed in mammals such as humans [1]
After virus identification and isolation, the pathogen for this pneumonia was originally called 2019 novel coronavirus (2019-nCoV). 2019-nCoV has been associated with progressive cytokine storm leading to a hyper-inflammatory state that this state associated with respiratory failure
We hereby reported a known case of Rheumatoid arthritis, Hypertension and Coronary artery bypass graft that confirmed 2019-nCoV and he was associated with progressive cytokine storm leading to respiratory failure

Summary

Introduction

Coronaviruses are enveloped RNA viruses of the family coronaviridae and broadly distributed in mammals such as humans [1]. While most human coronavirus infections are mild, 2019-nCoV can cause severe life-threatening complications, including acute respiratory distress syndrome, pneumonia, myocarditis, and organ failure [5]. Systemic Corticosteroids and 2019 Novel Coronavirus every 12 hours), losartan (25 mg, every 12 hours), and amilodipine (5 mg, daily) On initial examination, he had an elevated blood pressure of 155/95 mm Hg, regular tachycardia at 114 beats per minute, respiratory rate of 26 breaths per minute, and a pulse oximetric figure of 82%. Cytokine storm syndrome with respiratory failure was diagnosed; no response to treatment was noted after five days of hospitalization, so pulse-doses of methylprednisolone at 260 mg daily were prescribed for three days, and the patient's general condition improved significantly.

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