Abstract
A recent editorial review in this journal [1] discussed whether MRI was fulfilling its promise for molecular imaging of cartilage in osteoarthritis (OA) and related joint diseases. Many issues in the implementation of three MRI techniques (T2, T1rho, and dGEMRIC) were discussed in both clinical and high resolution environments. Although the theoretical bases of these MRI techniques are reasonably comprehensible, quantitative correlations between the values of these MRI parameters and the healthy states of the cartilage tissue have not yet been proved to be reliable and consistent in clinical trials of OA. The authors [1] concluded accurately that “the factors associated with cartilage degeneration may have differential and competing effects” on the values of these parameters. In this short note, we would like to participate in this discussion by exploring the influence of an additional factor, the image resolution, in MRI of cartilage, based on our limited experience in microscopic imaging of cartilage using T2 relaxation and in quantitative correlation among several microscopic imaging techniques.
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