Resolution enhancement of digital holographic microscopy via synthetic aperture: a review

Abstract

Digital holographic microscopy (DHM), which combines digital holography with optical microscopy, is a wide field, minimally invasive quantitative phase microscopy (QPM) approach for measuring the 3D shape or the inner structure of transparent and translucent samples. However, limited by diffraction, the spatial resolution of conventional DHM is relatively low and incompatible with a wide field of view (FOV) owing to the spatial bandwidth product (SBP) limit of the imaging systems. During the past decades, many efforts have been made to enhance the spatial resolution of DHM while preserving a large FOV by trading with unused degrees of freedom. Illumination modulation techniques, such as oblique illumination, structured illumination, and speckle illumination, can enhance the resolution by adding more high-frequency information to the recording system. Resolution enhancement is also achieved by extrapolation of a hologram or by synthesizing a larger hologram by scanning the sample, the camera, or inserting a diffraction grating between the sample and the camera. For on-chip DHM, spatial resolution is achieved using pixel super-resolution techniques. In this paper, we review various resolution enhancement approaches in DHM and discuss the advantages and disadvantages of these approaches. It is our hope that this review will contribute to advancements in DHM and its practical applications in many fields.