Abstract
Objectives: Ovarian cysts often resolve but little information on this resolution is available to the practicing physician. The objective of this study was to characterize the resolution of incident ovarian cysts in relation to cyst diameter, structure, age, body habitus, and menopausal status. These characterizations are important for decisions to continue surveillance or intervene surgically. Methods: A total of 2,638 women with incident cysts were selected who had undergone 51,356 TVUS examinations in the University of Kentucky Ovarian Cancer Screening Program. Prevalent cysts were excluded as they would be examined with an undefined course of first appearance when defining resolution time. Other exclusions included women with concurrent ovarian malignancies, cysts with solid components, and cases where surgery interrupted the natural history of measured cysts. In the incident population of women with cysts, both resolving and persisting cysts were evident. The descriptor reported here is cyst diameter in order to relate the findings to physicians discovering these structures by bimanual examination. The variables that were collected were: age, BMI, cyst diameter, cyst structure (loculation/septation), family history of ovarian cancer, and use of hormone replacement therapy. All images were reviewed by a physician. Methods of analysis include t-tests, chi-square, and Cox regression analysis of cyst resolution times. Download : Download high-res image (200KB) Download : Download full-size image Results: Women with a history of more than 1 cyst were included so that 2,465 unilocular and 1,420 septated cysts were available for analysis. Cyst size was normally distributed. Septated cysts (mean±SEM, 3.8±0.03), had a larger diameter than unilocular cysts (3.4±0.03), P Conclusions: Although septated cysts had a larger diameter than unilocular cysts, they resolved faster. Resolution of unilocular cysts was fastest in women 70+ years and most prolonged in women
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