Abstract

Racemic dimethyl hydroxy-(ferrocenylmethyl)phosphonate rac- 1 was resolved via the formation of diastereomeric esters with ( S)-α-methoxy-α-phenylacetic acid. The diastereomers, separated by column chromatography, were stereospecifically hydrolyzed by dissolution in trifluoroacetic acid at −30 °C and quenching with water. The absolute configuration of one enantiomer of 1 was assigned by X-ray diffraction.

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