Abstract
We recently observed that an inspiratory flow-resistive load can worsen airflow obstruction in supine asthmatic patients. As such loads reportedly augment intrapulmonary blood volume, we examined the effect of a prolonged inspiratory resistive load on pulmonary capillary volume (corrected for alveolar volume—Vc/Va) in 15 asthmatic and 4 normal subjects. Subjects inspired continuously while supine through increasing resistances (hour 1, 9.0; hour 2, 17.0, and hours 3 and 4, 21.5 cm H2O/L/s).
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