Abstract
Obesity is a highly prevalent disease over the world. The metabolic effects of obesity are one of the most common risk factors for atherosclerosis. Insulin resistance may be a potential mechanism whereby obesity leads to cardiovascular diseases. A novel adipokine, resistin, is named for its insulin resistance property, and it can be done linkage between obesity and cardiovascular diseases. Expression of cell adhesion molecules by the endothelium and the attachment of monocytes to endothelium may play an important role in the early stage of cardiovascular diseases, such as atherosclerosis. Origanum majorana L. has been known to possess medicinal effects and exhibit antioxidative properties. Previous studies indicated that carnosic acid and ursolic acid are the major compounds in Origanum majorana L.. In this study, we investigated the antioxidative effects of carnosic acid and ursolic acid in vitro. The effects of carnosic acid and ursolic acid on the adhesion of U937cells to resistin-induced human umbilical vein endothelial cells (HUVECs), as well as on the expression of adhesion molecules were examined. Furthermore, we also observed the effect of these two compounds on the formation of intracellular reaction oxygen spiecies (ROS) and the effect on nuclear factor-κB (NF-κB) p50, p65. Our results indicated that carnosic acid and ursolic caid had antioxidative activities in vitro. Both of them can suppress resistin-induced the adhesion of U937 to HUVECs and the production of ROS. Both of them also suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1), and endothelial cell selectin by Western blot assay. Besides, they attenuated or blocked resistin-induced NF-κB p50/ p65. In conclusion, carnosic acid and ursolic acid have anti-inflammatory property and inhibit resistin-inducd atherosclerosis, suggesting that Origanum majorana L. may play a protective role in obesity-induced cardiovascular diseases.
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