Resistin is increased in intra-abdominal sepsis: Correlation with proinflammatory cytokines and Acute Physiology and Chronic Health Evaluation II scores

Abstract

levels, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and mortality. Method and Patients: A total of 45 patients with intra-abdominal sepsis from the General Surgery Intensive Care Units of Gazi University School of Medicine and Zonguldak Karaelmas University School ofMedicinewere included in the study. Eighteenwith sepsis, 14 patients with severe sepsis, and 13 with septic shock were investigated. After the diagnosis of sepsis, blood samples were taken on the next 5 days. All patients were followed for 28 days and mortalities were noted. Adiponectin and cytokine levels and routine biochemistry were measured daily during the first 5 days after admission and were correlated to other cytokines, APACHE II scores, and mortality. Results: Forty-five patients were studied, 12 of whom died within 28 days. Although serum adiponectin levels were significantly higher than in the control group, the levels of septic shock and severe sepsis were significantly lower than in the septic patients. Serum adiponectin levels negatively correlated with interleukin-6, interleukin-1β, tumor necrosis factor-α, procalsitonin, lactate, and APACHE II. Serum adiponectin levels of the dead patients were significantly lower than those of surviving patients. Conclusions: Serum adiponectin levels in patients with intraabdominal sepsis were negatively correlated with proinflammatory cytokines and APACHE II levels. It can be used as a strong negative predictive factor for mortality.