Abstract
Breast milk contains adipokines such as resistin and leptin and is known for its protective effect against obesity and insulin resistance. This pilot study aims to evaluate the correlation between resistin levels, feeding types (breast milk and formula), and anthropometric parameters in healthy 1-month-old term infants. Urine and breast milk samples were collected from 32 infants and their mothers at 1 month postpartum. Twelve infants were included in the breastfed group, while thirteen infants comprised the breastfed-dominant mix-fed group, and seven infants the formula-dominant mix-fed group. Using ELISA kits, we analyzed resistin levels in the infants’ urine and the mothers’ breast milk, and leptin levels in breast milk. Urinary resistin levels among the three groups were not significantly different. There was no correlation between the following: urinary resistin levels in the breastfed group with resistin levels in breast milk; resistin levels in urine with infant’s body weight and weight gain; resistin levels in breast milk with weight, age, and BMI of mothers and leptin levels in breast milk. This study suggests that the type of feeding does not affect resistin levels in term infants and resistin level does not affect growth in early infancy.
Highlights
Academic Editor: Maurizio AricòBreastfeeding is recommended as the optimal source of nutrition for infants, to support their growth and development as well as long-term health [1]
There were no significant differences in the age and anthropometric indices of mothers and infants among the three groups (Table 1)
We found no correlation between urinary resistin levels with body weight, weight gain at 1 month, and body mass index (BMI) (Figure 2)
Summary
Breastfeeding is recommended as the optimal source of nutrition for infants, to support their growth and development as well as long-term health [1]. The protective role of breast milk can be attributed to its nutritional composition such as proteins, and bioactive substances that have been recently investigated. Bioactive substances such as adipokines are involved in the development of physiological functions [4]. Resistin was first discovered in 2001 and it is an adipocyte-derived secretory factor. Along with leptin and adiponectin, resistin belongs to the group of adipocytokines [5]
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