Resistencia antibiótica del Propionibacterium acnes en pacientes tratados por acné vulgar en Málaga

Abstract

Abstract.—Introduction: acne vulgaris is a multifactorial disease of the pilosebaceous follicle inwhich Propionibacteria acnes are thought to play an important role in the pathogenesis.The aim of this study was: a) to document the use of topical and systemic antibiotics amongst the population of acne sufferers in Malaga; b) to quantify the number of Propionibacterium acnes resistant strains for each antibiotic, and c) to compare the level of resistance of these strains to the antibiotics used. Patients and method: in 1999 samples were taken from the surface of the facial skin of 88 consecutive patients in the private practice.The system used was that routinely followed at the acne clinic at Leeds University, England. Results: half of the patients studied had received treatment for acne along with topical and systemic treatment. Almost all patients studied (97.5%) used topical erythromycin; topical clyndamycin was used by 20.4%. Minocicline was the systemic antibiotic most opted for (52%). Erythromycin was the antibiotic with the most resistant strains (55.8%) followed by clindamycine (51.8%). Propionibacterium acnes was sensitive to minocicline in 97.7% of the cultures and tetracycline in 95.5% of them. Conclusions: the topical antibiotics used were those which presented the highest percentage of resistence whereas the systemic antibiotics used with on patients showed high sensitivity indices.