Abstract
This review describes the multi-drug-resistant pathogens that lead to the most life-threatening infections, and the current state of prevention and management strategies used in clinical and emergency care. New methods of early detection and screening, novel combination antibiotics, and adjuvant therapy with a better understanding of the mechanisms employed by multi-drug-resistant bacteria are in the forefront of this impending public health crisis. The incidence of infections caused by multi-drug-resistant pathogens is rising. A robust and concerted international response from the medical and public health communities is needed. The early identification of antibiotic-resistant pathogens and the appropriate targeted antibiotic therapy are the major determinants of decreased mortality. Antibiotic stewardship to slow the rate of antibiotic resistance and research and development of novel antibiotics must be encouraged and supported financially. Providers must also be vigilant with hand hygiene and environmental decontamination in all healthcare settings.
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