Abstract
Invasive fungal infections,especially candida spp infection,are increasing with the development of medical technology and economy in recent years.Azoles have many advantages in treating fungal infections.More and more resistance strains appear in clinical treatment because of the widely use of azoles.Therefore,research of the molecular mechanisms involving in azoles resistance is a serious imminent issue.ERG11 is a key enzyme in the ergosterol synthesis pathway of candida spp.Point mutations and over-express in ERG11 are deemed as one of the most important mechanisms of azoles resistance.The aim of this study is to systematically review the resistant mechanisms of ERG11 gene of candida to azoles. Key words: Candida; Antifungal resistance; Azoles; Mechanisms; ERG11 gene
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