Abstract
The resistance of Candida albicans to azoles has attracted more and more attention due to the increasing use of azoles. Molecular mechanisms of azole resistance that have been described for C. albicans include point mutation or overexpression of ERG11 gene, increased efflux of drugs followed by decrease of intracellular drug concentration, biofilm formation, etc. Recently, more and more attention has been paid to the relationship between zinc cluster transcription factor family and drug resistance. It has been revealed that point mutations at zinc cluster transcription factor family genes such as UPC2, TAC1 and MRR1 will causeoverexpression of related genes, which in turn contributes to azole resistance of C. albicans. Key words: Candida albicans; Triazoles; Imidazoles; Drug resistance
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