Abstract

The discovery that treatment of Kawasaki disease with intravenous immunoglobin (IVIG) could improve symptoms and lower the risk of developing coronary artery aneurysms was a major breakthrough. Now children with Kawasaki disease are routinely treated with IVIG and the outcome has greatly improved. A vexing problem is the patient with Kawasaki disease who is resistant to treatment with (IVIG). The mechanism underlying this non-response has not been clear. A Polymorphism in Plasma Platelet-activating Factor Acetylhydrolase is Involved in Resistance to Immunoglobulin Treatment in Kawasaki DiseaseThe Journal of PediatricsVol. 147Issue 1PreviewTo investigate whether reduced levels of plasma platelet-activating factor acetylhydrolase (PAF-AH) as a result of a genetic polymorphism are involved in the pathogenesis of Kawasaki disease (KD). Full-Text PDF

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