Abstract
Abstract This chapter deals with the biochemical mode of action of quinone outside inhibitor (QoI) fungicides, which are respiration inhibitors; their fungicidal activity comes from their ability to inhibit mitochondrial respiration by binding at the so-called Qo site (the outer quinol-oxidation site or ubiquinol site) of the cytochrome bc1 enzyme complex (complex III), located in the inner mitochondrial membrane of fungi and other eukaryotes. It discusses the resistance risk to the QoIs; history of resistance to these fungicides; mutations associated with QoI resistance; and the monitoring for resistance to QoI fungicides. It is hoped that the experience of the QoI fungicides will help learning for the future novel classes of fungicides that will be introduced.
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