Abstract
Abstract A strain of T. evansi was made drug-fast to quinapyramine, suramin, stilbamidine and tryparsamide, respectively by treating mice with gradually increasing subcurative doses, passage of the relapse strain, and so on. The resistance exhibited to neutral aromatic arsenicals, melaminyl compounds, derivatives of acridine, diamidine and phenanthridine, and quinapyramine and suramin was analysed. Strains resistant to quinapyramine and suramin showed no cross-resistance. Stilbamidine resistance was accompanied by resistance to the neutral aromatic arsenicals (oxophenarsine), to melaminyl compounds (melarsoprol and MSb), a derivative of acridine (acriflavine and tryparsamide), the other diamidine-diminazene, and to the phenanthridine compound metamidium, but not to quinapyramine and suramin. The tryparsamide-resistant strain showed cross-resistance to the structurally related oxophenarsine, but was fully susceptible to other trypanocides.
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