Resistance of Klebsiella Pneumoniae Isolated From Different Infections to Antibiotics

Abstract

During the period (September, 1998-March, 1999), 95 isolates of Klebsiella from respiratory tract, urinary tract, middle ear, intestinal tract, wound and blood infections were collected.. Morphological studies and biochemical tests were used for the identification of this bacterium. (50) isolates of Klebsiella pneumoniae were selected and used in the study. It was found that all isolates were resistant to one or more antibiotic and that Amikacin was the most active antibiotic against this species as all isolates were susceptible to it. Also Ciprfloxacin and Norfloxacin were very active with resistance rates of (8 %) and (14 %) respectively. Middle ear isolates were found to be more susceptible to antibiotics whereas blood and intestinal tract isolates were highly resistant to them. The study indicated that this bacterium has a high ability to produce -lactamase enzymes with total production rate of (88 %). The production rate of extended spectrum -lactamases was (36 %) where blood and intestinal tract isolates gave rates of (100 %) and (66.7 %) respectively, whilst urinary tract isolates gave rate of (55.6 %), whereas the production rate of respiratory tract and wound isolates was (25 %) for each. Middle ear isolates didn’t produce these enzymes