Abstract
Abstract Heavily irradiated mice of several inbred and F1 hybrid strains were classified as resistant or susceptible to allogeneic or parental grafts of 106 NZB bone marrow cells depending on the 5-day hemopoietic repopulation of host spleens. Several strains did not support the growth of donor cells despite the total-body irradiation. NZW × NZB F1 mice resisted the growth of as many as 4 × 107 parental cells, the strongest barrier ever observed in mice for marrow transplants. The failures of growth were due to host-anti-graft reactions depressible by pretreatment of recipients with cyclophosphamide or horse anti-mouse thymocyte serum. Analysis of the progeny of two separate backcrosses of F1 mice to NZB indicated that two non-linked autosomal genes controlled resistance. One of these genes was in linkage group IX, 31.42 crossing-over units away from the D end of H-2, specifying or controlling the expression of alloantigen-like components of hemopoietic cells (Hh-gene). The second gene had an epistatic effect, probably by regulating the recognition of, or the reactivity to, Hh-gene products.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
