Abstract
Group A β-hemolytic streptococcus (GAS), namely Streptococcus pyogenes, is one of the most important human pathogen.GAS can cause skin and mucous membrane superficial infectious diseases, life-threatening invasive disease, toxin-mediated diseases and immune-related diseases.Antibiotic is an effective mean to control GAS infection.The β-lactam antibiotics remain the first-choice treatment for GAS infection and the macrolides are often recommended as a replacement therapy for β-lactam antibiotics allergic patients or a means to blocking GAS exotoxin product.But with the widespread use of macrolides autibiotics, macrolide-resistant GAS spread in the world.This paper will elaborate the situation of macrolide-resistant clones. Key words: Group A β-hemolytic streptococcus; Macrolide antibiotics; Resistance
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