Abstract
Background: Routine lung function testing requires expensive equipment, or requires maximum expiratory effort. The airflow perturbation device (APD) is a light handheld device, allowing for serial measures of respiratory resistance noninvasively and effortlessly. Methods: In a convenience sample of 398 patients undergoing pulmonary function testing, we compared routine spirometric indices (forced expired volume in 1 second (FEV1), peak expiratory flow (PEF)), and airways resistance (Raw-272 patients), to measures of respiratory resistance measured with the APD including inspiratory (IR), expiratory (ER) and averaged (AR) resistance. Results: Measures of lung function were significantly correlated (p 0.001). On regression analysis, between 7% - 17% of the variance (R2) for FEV1, PEF, and Raw was explained by APD measurements. Approximately 2/3 of the variance in FEV1 was explained by PEF measurements. Conclusions: APD measurements of lung function correlate with conventional measures. Future studies should be directed at exploring the use of the APD device in serial measures of lung function in patients with lung disease.
Highlights
Airway resistance is a commonly used measurement of lung function in a variety of respiratory disorders
In a convenience sample of 398 patients undergoing pulmonary function testing, we compared routine spirometric indices (forced expired volume in 1 second (FEV1), peak expiratory flow (PEF)), and airways resistance (Raw-272 patients), to measures of respiratory resistance measured with the airflow perturbation device (APD) including inspiratory (IR), expiratory (ER) and averaged (AR) resistance
We hypothesized that APD measurements of resistance would be significantly correlated with standard laboratory measures of lung function
Summary
Airway resistance is a commonly used measurement of lung function in a variety of respiratory disorders. Whole-body plethysmography is commonly used to measure airways resistance [1] This technique requires coordinated breathing maneuvers coached by a skilled technician and a large non-portable and expensive apparatus. Another technique for measurement of pulmonary resistance (airways resistance and lung tissue resistance) is the technique of von Niergard and Wirz [2]. Forced oscillation, originally designed to measure respiratory impedance during tidal breathing [3] has been shown to be sensitive to changes in airways resistance [4]. We hypothesized that APD measurements of resistance would be significantly correlated with standard laboratory measures of lung function
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