Abstract
BackgroundOveractivation of the stress response can influence cancer outcomes through immune-related pathways. Adolescents and young adults (AYAs) undergoing hematopoietic cell transplantation (HCT) are at risk for poor outcomes, yet there are limited behavioral interventions and no psychosocial biomarker data for this population. The Conserved Transcriptional Response to Adversity (CTRA) is an inflammation-related pattern observed in conditions of heightened stress and is associated with HCT outcomes. ObjectiveThe objective of the current study was to explore the CTRA gene regulatory impact of the PRISM intervention among AYAs receiving HCT. We hypothesized that patients who received the intervention would have favorable gene expression signatures compared to those in the control arm. Study DesignThis was an ancillary study within a randomized trial testing the Promoting Resilience in Stress Management (PRISM) intervention on psychosocial outcomes among AYAs aged 12-24 years receiving HCT (NCT03640325). CTRA was quantified through genome-wide transcriptional profiles obtained from whole blood collected at baseline, 1-, and 3-months post HCT. Group differences in CTRA gene expression were estimated using mixed effect linear models. ResultsThere were no baseline group differences in CTRA expression, but PRISM participants showed a greater decline in CTRA at 1 month compared to controls (β -0.301 ± SE 0.114, p = 0.016), even when controlling for demographic (Group x Time interaction: F(2, 18) = 7.41, p = 0.004; β -0.386 ± 0.127, p = 0.007) and clinical covariates (Group x Time interaction: F(2, 20) = 7.03, p = 0.005; β -0.480 ± 0.144, p = 0.003). These differences were not detectable at 3 months (β -0.147 ± SE 0.120, p=0.235). ConclusionsThere was a change in stress-related gene expression among AYAs randomized to a psychosocial intervention. The stress-inflammation axis may be a targetable pathway in the AYA HCT population.
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