Abstract
This study was designed to determine ceftiofur sodium residues of different rabbit tissues after intramuscular injection at a dose of 2.2 mg/kg BW. A total of twenty-four healthy male New Zealand White rabbits were divided into two groups; the first group (n = 21) was injected with ceftiofur for five successive days, while the second group (n = 3) untreated (control). Liver, kidney, pectoral and thigh muscles, spleen, heart, blood and lung from each rabbit were collected at the 1st, 3rd, 5th, 7th, 9th, 15th and 21st day post ceftiofur sodium treatment. Tissues were extracted and ceftiofur residues were analyzed using high-performance liquid chromatography (HPLC). Ceftiofur remained within the detectable level till the 5th day in most of the investigated tissues (liver, kidney, lung, heart, pectoral and thigh muscles) and serum, but still detected till the 7th and 9th day post treatment in lung and kidney, respectively. It can be concluded that rabbit muscles and livers could be consumed safely at the 3rd day post treatment with that dose, while, rabbit kidneys could be consumed safely at the 1st day post treatment with that dose without any hazards on consumers because the residual level is below the recommended MRL.
Highlights
Over the last years, the food production system was changed to a large-scale production
Acceptance criteria: Relative standard deviation (RSD) ≤ 1% according to International conference on harmonization of technical requirements for registration of pharmaceuticals for human use (ICH, 2005) [7]
The high-performance liquid chromatography (HPLC) system was found precise as the Relative Standard Deviation (RSD) of 5 replicates of the toluene standard solution was 0.002%
Summary
The food production system was changed to a large-scale production. The administration of drugs to treat and/or prevent the spread of infections in food producing animals was increased [1]. Ceftiofur sodium is widely used for treating and preventing diseases of most domestic animals. There are little experimental data about its residues in rabbit tissues which was frequently detected [4]. Residues in different tissues of treated animals Material and Methods may increase the risk of antibiotic resistance or other adverse effects on people consuming. A total of twenty-four healthy male New. FAO established maximal residual limits Zealand White rabbits of 2±10 kg BW were (MRLs) for residues of drugs, pesticide and used in this study. The animals were housed in other chemical in the relevant tissues of food batteries at Post Graduate Research producing animals to protect and safeguard Laboratory, Pharmacology Department, human health
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
