Residue dissipation and dietary risk assessment of cyazofamid and its metabolite CCIM in garlic, garlic bolt and garlic sprout

Abstract

ABSTRACT The residue and dissipation dynamics of cyazofamid and its main metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile (CCIM) in garlic, garlic bolt and garlic sprouts were investigated by QuEChERS high-performance liquid chromatography–tandem mass spectrometry method. Field experiments were conducted in 6 sites for one year. The dietary intake risk of cyazofamid was assessed. At different levels, the results showed that the average recoveries of cyazofamid were 89.8%–1005% in garlic, 84.6%–109.4% in garlic bolt and 88.6%–108.5% in garlic sprout, recoveries of CCIM were 84.6%–104.2% in garlic, 84.6%–108.9% in garlic bolt and 85.3%–109.2% in garlic sprout, respectively, with relative standard deviation less than 10.1%. The limits of quantitation were all 0.01 mg/kg. The dissipation dynamics of cyazofamid and CCIM in garlic plant matrices fitted the first order kinetic equation, and the half-lives were 3.5–6.1 d and 0.9–3.9 d, respectively. The dietary intake risk assessment showed that the dietary exposure risk index of cyazofamid in garlic, garlic bolt and garlic sprout were less than 100%, which indicated that the dietary exposure risk was at an acceptable level.