Residual and compensatory changes of resting‐state EEG in successful recovery after moderate TBI

Abstract

Purpose: Even in years after recovery from moderate traumatic brain injury (moderate TBI), patients complain about residual cognitive impairment and fatigue. We hypothesized that non‐linear and linear resting‐state electroencephalography (rsEEG) features might also reflect neural underpinnings of these deficits. Methods: We analyzed a 10‐minute rsEEG in 77 moderate TBI‐survivors and 151 healthy volunteers after cognitive and psychological assessment. The rsEEG analysis included linear measures, such as power spectral density and peak alpha frequency, and non‐linear parameters such as Higuchi fractal dimension, envelope frequency, and Hjorth complexity. Results: The patients with moderate TBI had higher scores for fatigue and sleepiness and lower scores for mood and life satisfaction than controls. The behavioral test for directed attention showed a smaller and non‐significant between‐group difference. In rsEEG patterns, moderate TBI‐group had significantly higher deltaand theta‐rhythm power, which correlated with higher sleepiness and fatigue scores. The higher beta and lower alpha power were associated with a higher attention level in moderate TBI patients. Non‐linear rsEEG features were significantly higher in moderate TBI patients than in healthy controls but correlated with sleepiness and fatigue scores in both controls and patients. Conclusion: The rsEEG patterns may reflect compensatory processes supporting directed attention and residual effect of moderate TBI causing subjective fatigue in patients even after full physiological recovery.