Abstract
BackgroundFew modifiable risk factors for prostate cancer are known. Recently, disruption of the circadian system has been proposed to affect risk, as it entails an inhibited melatonin production, and melatonin has demonstrated beneficial effects on cancer inhibition. This suggests a potential role of traffic noise in prostate cancer.MethodsRoad traffic and railway noise was calculated for all present and historical addresses from 1987–2010 for a cohort of 24,473 middle-aged, Danish men. During follow-up, 1,457 prostate cancer cases were identified. We used Cox Proportional Hazards Models to calculate the association between noise exposure and incident prostate cancer. Incidence Rate Ratios (IRR) were calculated as crude and adjusted for smoking status, education, socioeconomic position, BMI, waist circumference, physical activity, calendar year, and traffic noise from other sources than the one investigated.ResultsThere was no association between residential road traffic noise and risk of prostate cancer for any of the three exposure windows: 1, 5 or 10-year mean noise exposure before prostate cancer diagnosis. This result persisted when stratifying cases by aggressiveness. For railway noise, there was no association with overall prostate cancer. There was no statistically significant effect modification by age, education, smoking status, waist circumference or railway noise, on the association between road traffic noise and prostate cancer, although there seemed to be a suggestion of an association among never smokers (IRR: 1.16; 95% CI: 1.00–1.36).ConclusionThe present study does not support an overall association between either railway or road traffic noise and overall prostate cancer.
Highlights
Prostate cancer is the second most common non-skin cancer in men worldwide [1], and the incidence is rising in most countries [2, 3]
There was no association between residential road traffic noise and risk of prostate cancer for any of the three exposure windows: 1, 5 or 10-year mean noise exposure before prostate cancer diagnosis
There was no association with overall prostate cancer
Summary
Prostate cancer is the second most common non-skin cancer in men worldwide [1], and the incidence is rising in most countries [2, 3]. Studies on sleep disruption and prostate cancer are few: One cohort study found a significant inverse association between sleep duration and prostate cancer risk [10], and a study on fatal prostate cancer found that short sleep duration (
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