Abstract
Small numbers of resident T lymphocytes are present in the dermis of normal skin of humans, cattle and sheep. We wanted to determine the prevalence, numbers and immunophenotype of lymphocytes in the dermis of healthy skin from alpacas. Skin biopsy specimens were collected from the dorsolateral thorax of 31 alpacas with normal skin. Skin biopsy specimens were evaluated for the prevalence and numbers of CD3+ and CD79a+ lymphocytes. Resident CD3+ and CD79a+ lymphocytes were found around the superficial and deep dermal blood vessels. The CD3+ lymphocytes were more numerous than CD79a+ lymphocytes. Both CD3+ and CD79a+ lymphocytes were more numerous around superficial dermal blood vessels. Resident CD3+ and CD79a+ lymphocytes are present around superficial and deep dermal blood vessels in normal skin from alpacas; hence, the presence of lymphocytes in these locations without obvious features of inflammation must be interpreted cautiously when evaluating skin biopsy specimens from alpacas with skin disease.
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