Abstract
Antiviral Immunity Memory T cells take up residence in the lung after respiratory virus infection to facilitate rapid and localized immune responses during reinfection. Two studies now identify a population of CD4+ tissue-resident helper T cells in mice that are Bcl6 dependent and support antiviral B cell responses within inducible bronchus-associated lymphoid tissue after influenza infection. Swarnalekha et al. used single-cell RNA sequencing of antigen-specific T cells across different tissues to characterize lung tissue–resident helper T cells and demonstrated that their development also requires B cells. Son et al. showed that tissue-resident helper T cells rely on the transcription factor Bhlhe40 for their survival and support protective CD8+ T cell responses by producing interleukin-21. These studies provide insight into the function of mucosal tissue–resident CD4+ T cells during viral infection. Sci. Immunol. 6 , eabb6808, eabb6852 (2021).
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