Abstract
The effect of hypo to hyperthermic temperatures on tumor blood flow and hypoxic cell fractions was studied in a murine fibrosarcoma transplanted in the hind leg of anesthetized mice. The blood flow to the tumor was assessed by the determination of the uptake of Thallium-201; the hypoxic cell fraction was estimated from cell survival curves derived from data based on lung colony assay. Over a temperature range of 18° to 46°C, the maximal blood flow occurred at 35°C which was approximately two times greater than that at room temperature (24°C) or at 39°C. The hypoxic cell fraction at 35°C was 11%, and was significantly less than that at 24°C or at 39°C. The hypoxic cell fractions at 24°C and at 39°C were 45% and 32°10, respectively. These results suggest that the optimal radiation sensitivity of peripherally located tumors can be obtained by warming the tumors to temperatures where maximal blood flow and minimal hypoxic cell fraction occur.
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