Proceedings of the Royal Society B: Biological Sciences | VOL. 289
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Reservoir population ecology, viral evolution and the risk of emerging infectious disease

Publication Date Sep 14, 2022

Abstract

The ecology and life history of wild animals influences their potential to harbour infectious disease. This observation has motivated studies identifying empirical relationships between traits of wild animals and historical patterns of spillover and emergence into humans. Although these studies have identified compelling broad-scale patterns, they are generally agnostic with respect to underlying mechanisms. Here, we develop mathematical models that couple reservoir population ecology with viral epidemiology and evolution to clarify existing verbal arguments and pinpoint the conditions that favour spillover and emergence. Our results support the idea that average lifespan influences the likelihood of an animal serving as a reservoir for human infectious disease. At the same time, however, our results show that the magnitude of this effect is sensitive to the rate of viral mutation. Our results also demonstrate that viral pathogens causing persistent infections or a transient immune response within the reservoir are more likely to fuel emergence. Genetically explicit stochastic simulations enrich these mathematical results by identifying relationships between the genetic basis of transmission and the risk of spillover and emergence. Together, our results clarify the scope of applicability for existing hypotheses and refine our understanding of emergence risk.

Concepts

Viral Evolution Transient Immune Response Risk Of Spillover Viral Epidemiology Life History Of Animals Infectious Disease Persistent Infections Viral Pathogens Traits Of Animals Reservoir For Disease

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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