Abstract
A voluminous literature has accumulated on the efficacy of reserpine in mental disorders, particularly in psychoses accompanied by uncontrolled behavior. As yet few reports have included double-blind controls with a published breakdown of the specific areas of clinical change. Hollister * found the dosage to be the most influential factor in a series of studies using varied doses, with the results expressed in terms of hospital adjustment. Hoffman and Konchegul,<sup>3</sup>Campden-Main and Wegielski,<sup>4</sup>and, more recently, Sommerness,<sup>5</sup>Forster,<sup>6</sup>and Cowden<sup>7</sup>reported similar studies. The present study was intended primarily to determine an effective dosage of reserpine in chronic disturbed schizophrenic women, using a double-blind technique, for comparison with the effect of administering placebos and of giving no medication at all. It was hypothesized that in adequate dosage reserpine will effect tranquilization of chronically disturbed psychotic women. In order to test this, it was necessary (1) to
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