Resection of anterior skull base meningiomas via endonasal approach and craniotomy: a Meta-analysis

Abstract

Objective To evaluate the clinical efficacy of resection of anterior skull base meningiomas via endonasal approach and craniotomy. Methods Comparison of the randomized and non-randomized controlled trials of resection of anterior skull base meningioma via endonasal approach and craniotomy both at home and abroad were enrolled by retrieving PubMed, Ovid, Cochrane Library, Embase, Wanfang, VIP, Chinese Journal Full-text Database, and manual retrieval. The literature was selected, the data were abstracted, and they were checked crossly by 2 independent reviewers. RevMan 5.3 software was used for statistical analysis. Results After screening, 6 articles were enrolled. A total of 182 patients were used as the objects, 68 of them were in the transnasal group and 144 were in the craniotomy group. There was no significant difference in postoperative cerebrospinal fluid leakage between the transnasal group and the craniotomy group (OR=3.16; 95% CI 1.26-7.90; P=0.01). There were no significant differences in the total tumor resection rate, endocrine disorder, infection, recurrence, visual improvement, and visual deterioration between the 2 groups (all P>0.05). Conclusions According to the current literature available, the resection of anterior skull base meningiomas via nasal approach could achieve the effect of total resection of craniotomy. Although there were no significant differences in the postoperative visual effects, infection, endocrine disorders and recurrence between the two, the craniotomy has some advantages in the aspect of controlling postoperative cerebrospinal fluid leakage. Key words: Meningioma; Skull base; Endonasal; Craniotomy; Meta-analysis