Abstract
BackgroundMediastinal lipoma/liposarcoma is a rare tumor of the mediastinum.Case presentationThis article reported one case of giant anterior superior mediastinum well-differentiated liposarcoma involving the left thoracic cavity with symptom of dysphagia. The mediastinum liposarcoma was completely resected through a left thoracotomy. Histologic examination and molecular pathological test clarified the diagnosis as well-differentiated mediastinal liposarcoma. There has been no evidence of recurrence during the 8 months follow-up.ConclusionMolecular pathological examination of the MDM2, CDK4 and p16 gene in tumors provides the diagnostic gold standard in distinguishing well-differentiated liposarcoma from lipoma. Complete surgical resection is the first-line treatment choice for mediastinal lipoma/ liposarcoma.
Highlights
Lipoma and well-differentiated liposarcoma are wellcircumscribed mesenchymal tumor which originate from adipose tissue [1]
Mediastinal lipoma and liposarcoma are rare tumors of the mediastinum, which mainly occurred in the anterior mediastinum, and constituted 1.6–2.5% of primary mediastinal tumors [2]
We reported one case of anterior superior mediastinum well-differentiated liposarcoma involving the left thoracic cavity with symptom of dysphagia
Summary
Lipoma and well-differentiated liposarcoma are wellcircumscribed mesenchymal tumor which originate from adipose tissue [1]. Mediastinal lipoma and liposarcoma are rare tumors of the mediastinum, which mainly occurred in the anterior mediastinum, and constituted 1.6–2.5% of primary mediastinal tumors [2]. We reported one case of anterior superior mediastinum well-differentiated liposarcoma involving the left thoracic cavity with symptom of dysphagia. Chest CT scan revealed a huge mass with fat density in the anterior superior mediastinum and left lung field, the inferior lobe of left lung was compressed, trachea and heart shifted to the right side (Fig. 1). Except ferritin with a high value of 420.9 ng/mL, showed normal values. The boundary of the tumor was clear, which had some adhesion to the chest wall, and the tumor was
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