Resection margin status and HPV DNA test as predictor of residual lesion after cervical conization in the management of CIN 3

Abstract

Objective:To identify resection margin status and HPV DNA test as predictive factors for residual lesion in the management of CIN2 with cervical conlzation. Methods: A retrospective study was conducted on 96 patlents with CIN3 who had been performed cervical conlzation (LEEP or CKC) between January 1999 and December 2003 at Soonchunhyang university Chunan hospital. Secondary conization or hysterectomy were performed in case of positive margin on cone specimen or negative margin with other hysterectomy indication. Resection margin status and pre conization HPV DNA test were compared with residual lesion on subsequent cone or hysterectomy apecimen. Results:Among 96 cases, 24 cases (15.6%) showed positive resection margin on cone specirnen.Of 24 cases with positive resection margin, 2 cases were with negative resection margin, hysterectomy was performed due to other indication in 16 cases. Persistence of residual lesion in the secondary conization and hysterectomy specimans was significantly correlated with high risk HPV infection and positive resection margin status(p