Resection is safe for patients with stage IIIA NSCLC undergoing multimodality therapy

Abstract

Abstract Background Controversy continues regarding the optimal therapy for stage IIIA non-small cell lung cancer (NSCLC). Improved survival has been shown in patients undergoing multimodality therapy that includes surgical intervention. Methods Stage IIIA NSCLC demographics, post-treatment survival, complications and survival rates were compared with stage I and stage II NSCLC. Results Mean age for patients from all groups was over 60 years ( p =0.66). They had similar BMI ( p =0.35) and the majority of the patients in all groups were females ( p =0.51). Lobectomy was the most used procedure in all three groups; 93% in patients with stage I NSCLC, 73% and 76% in patients with stage II and IIIA, respectively ( p p 24h; 3%) than patients in stage I ( p =0.032). Median hospital length of stay was 3 days for stage II and IIIA patients and 2 days for patients with stage I ( p Conclusions Pulmonary resection as an initial therapy or following neoadjuvant radiation and chemotherapy is safe for patients with stage IIIA NSCLC. Locally advanced disease does not confer increased risk of perioperative morbidity or mortality in our study population.