Researching on the solution variation of double-concave disc-shaped vesicle of alcoholism blood cells

Abstract

The physical model of the interaction between ethanol and blood cells has been established by the biomembrane surface elasticity theory. Under the universal equation of double-concave disc-shaped bubble, the analytical solution has been deduced. It confirmed theoretically that ethanol could lead to the larger volume of red blood cells. The fluorescence experiment result verified this conclusion. When ethanol goes into the red blood cells, the changing osmotic pressure causes cells’ vertices moving to the center, and double-concave disc surface will be the spherical one. It results in the larger volume of the red blood cell and smaller surface area, and thus causes the ratio of the surface area to volume decrease significantly. So the resistance tensile capacity of red blood cells reduced. Alcoholism can cause blood viscosity and the clinical test result coincide this conclusion. This study can give certain reference for the research of mutual function mechanism between ethanol and blood cells.