Research status on pathogenesis of myocardial depression in sepsis

Abstract

The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a common finding associated with increased morbidity and mortality.Myocardial depression during sepsis is not clearly defined, but it can perhaps be best described as a global (systolic and diastolic) dysfunction of both the left and right sides of the heart.The pathogenesis of septic myocardial depression involves a complex mix factor of genetic, molecular, metabolic, and structural.Now, the research status on pathogenesis of myocardial depress in sepsis was reviewed. Key words: Myocardial depression; Dysfunction of heart; Sepsis; Septic shock