Abstract
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with limited treatment options and high rates of recurrence and metastasis due to the lack of specific therapeutic targets. The incidence of bone metastases and brain metastases is also high. They are more likely to relapse and have a poor long-term prognosis. The tumor microenvironment (TME) consists of tumor cells, a variety of mesenchymal cells and an extracellular matrix, which together induce tumor proliferation, stimulate angiogenesis, inhibit cell apoptosis and regulate the immune system, thereby blocking TNBC’s anti-tumor response and promote TNBC’s progression and metastasis. TNBC has unique TME, and TME may be a potential therapeutic target for TNBC. However, the overall pattern of TME phenotypes remains unknown. Because microenvironment cells have dense crosstalk, it is more reasonable to consider them as a whole. This article will review the TME characteristics of TNBC and the latest progress of TNBC microenvironment immunotherapy.
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