Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the worst digestive malignancies. The prognosis of this disease remains dismal since the facts that it is difficult to be diagnosed in early stage, has a low rate of surgical resection, and is not sensitive to conventional chemoradiotherapy. Cellular senescence refers to stable cell cycle arrest caused by DNA damage or oncogene dysregulation, accompanied by the changes in morphology, chromatin, and gene expression. Recent studies have found that a variety of factors can induce senescence of pancreatic cancer cells. These senescent cells could interact with neighboring cells through the senescence-associated secretory phenotype, and thereby participate in tumorigenesis and development and contribute to dismal prognosis. This article reviews the research status and progression of the biological significance, regulatory mechanisms and senotherapy of senescent cells in PDAC. Key words: Pancreatic ductal adenocarcinoma; Cellular senescence; Senescence-associated secretory phenotype; Senotherapy
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