Research status and progress of bone marrow mesenchymal stem cells for osteonecrosis of femoral head

Abstract

Osteonecrosis of femoral head (ONFH) is a progressive, destructive disorder with no targeted treatment currently available. The etiology of this disease is complex and the pathogenesis is not clear. The main clinical manifestations are hip pain and mobility dysfunction, which threatens human health to a large extent. If not timely intervention and treatment in the early and middle stages of ONFH, femoral head deformation and even collapse are easy to occur, seriously affecting the prognosis of patients. Therefore, early identification and treatment of ONFH is very important. With the development and maturity of regenerative medicine and tissue engineering technologies, studies have shown that Bone marrow mesenchymal stem cells (BMSCs) combined with cardiac decompression, autologous bone transplantation, arterial interventional therapy, and tissue engineering techniques, it has certain curative effect on early and middle stage ONFH. This paper mainly discusses the research status and progress of BMSCs in the treatment of ONFH, in order to provide theoretical basis for the treatment of ONFH with BMSCs.