Abstract
In a meta-analysis of 56 clinical trials (n=4060), Grant Shields and colleagues examined links between 8 psychosocial interventions and 7 markers of immune system function. Analysis showed an association between psychosocial interventions and improvements in immune system function (pretest-posttest-control group effect sizes=0·30 [95% CI 0·21–0·40]; p<0·001). Allocation to a psychosocial intervention compared with a control modality was associated with attenuation of harmful immune system function and enhancement of beneficial immune system function, with benefits lasting at least 6 months after stopping treatment. The type of psychosocial intervention affected outcomes, with further analysis suggesting that enhanced immune function was most consistent after cognitive behaviour therapy (p<0·001) and multiple or combined interventions (p=0·01). Effectiveness of a brief lay counsellor-delivered, problem-solving intervention for adolescent mental health problems in urban, low-income schools in India: a randomised controlled trialA brief lay counsellor-delivered problem-solving intervention combined with printed booklets seemed to have a modest effect on psychosocial outcomes among adolescents with diverse mental health problems compared with problem-solving booklets alone. This counsellor-delivered intervention might be a suitable first-line intervention in a stepped care approach, which is being evaluated in ongoing studies. Full-Text PDF Open Access
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