Research Round Up

Abstract

With data from a systematic review and meta-analysis, Mikaïl Nourredine and colleagues assessed the risk of developing a psychotic disorder following a childhood diagnosis of attention-deficit hyperactivity disorder (ADHD). Researchers included data for participants younger than 18 years at the time of ADHD diagnosis in their review, and 12 observational studies were included in the meta-analysis. With data from 124 095 individuals with ADHD and 1 725 760 controls, their analysis suggested that having an ADHD diagnosis was associated with an increased risk of subsequently developing a psychotic disorder (pooled relative effect 4·74 [95% CI 4·11–5·46]; I2=43% [95% CI 0–70%]). The interaction of cognitive and brain reserve with frailty in the association with mortality: an observational cohort studyHigher cognitive reserve and higher brain reserve were associated with a lower mortality risk. Additionally, cognitive reserve and frailty interact in the association with mortality, such that higher cognitive reserve is particularly associated with lower mortality in frail participants. Full-Text PDF Open AccessPrevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysisThere is a high prevalence of symptoms of anxiety and depression in patients with IBD, with up to a third of patients affected by anxiety symptoms and a quarter affected by depression symptoms. Prevalence was also increased in patients with active disease: half of these patients met criteria for anxiety symptoms and a third met criteria for depression symptoms. Encouraging gastroenterologists to screen for and treat these disorders might improve outcomes for patients with IBD. Full-Text PDF Negative impact of the first COVID-19 lockdown upon health-related behaviours and psychological wellbeing in people living with severe and complex obesity in the UKThis study shows the detrimental impact of the first COVID-19 lockdown on PLWO in relation to health-related behaviours, mental health and access to WMS. Our findings show that PLWO with poor mental health and those attending WMS were most adversely impacted and highlights the need for greater mental health support and continued provision of support from WMS for PLWO during future lockdowns. Full-Text PDF Open Access