Research progression on relationship between angiosteosis and matrix vesicle

Abstract

Angiosteosis is associated with increased vascular stiffness and leads to clinical manifestations such as high blood pressure and heart failure, which increases the risk of cardiovascular morbidity and mortality. Angiosteosis is considered to be ectopic deposits of calcium phosphate crystallization in the form of hydroxyapatite in cardiovascular tissue. However, the mechanism of angiosteosis is not yet clear. The pathophysiologic process of angiosteosis is similar to normal bone mineralization. Matrix vesicles (MV) play an important role in bone mineralization. Researches confirmed the existence of MV in the calcified arteries under the microscope. Angiosteosis is widely found in clinical diseases, so the studies of the mechanism of angiosteosis and the role of MV in angiosteosis are of great significance. Key words: Secretory vesicles; Extracellular matrix; Blood vessels; Calcification