Abstract
The injury and failure diseases of human tissues and organs, such as heart failure and chronic kidney disease, seriously threaten human health and life safety. At present, however, organ transplantation has obvious limitations, and tissue engineering is considered as a potential alternative therapy. Tissue engineering uses the construction of cells, biomaterials and bioreactors to develop three-dimensional artificial tissues and organs for the enhancement, repair and replacement of damaged or diseased tissues and organs, which contributes to the fundamental solutions of diseases of tissues and organs as well as to the improvement of human health. This paper introduces the research progress of tissue engineering technology in the field of living organs from three aspects: seed cells, application of growth factors and biomimetic preparation of functionalized scaffold materials, hoping to provide help and ideas for the research and industrial development of the repair and reconstruction of human organs.
Highlights
The damage and dysfunction of organ tissue caused by various causes are important factors affecting human health and life safety
With the development of research on seed cells, the researchers have found that human amniotic mesenchymal stem cells, placental mesenchymal stem cells, bone marrow mesenchymal stem cells and adipose mesenchymal stem cells have the characteristics of low immunogenicity, which can inhibit the proliferation and function of major immune cell groups, including T cells, and they are easy to isolate and culture, and have pluripotent differentiation.[18]
This paper mainly introduces the research progress of three core elements of tissue engineering in the application of vital organs -- seed cells, growth factors and biomimetic scaffold materials
Summary
The damage and dysfunction of organ tissue caused by various causes are important factors affecting human health and life safety. Tissue engineering is a multidisciplinary field, involving stem cell technology, biotechnology, chemical materials and other fields, through the application of cell, biomaterial and bioreactor construction to develop three-dimensional artificial tissues and organs. This technique can be used to strengthen, repair and replace damaged or diseased tissues, and to provide treatment for a number of persistent diseases, such as malignant tumors, diabetes, heart disease, Alzheimer's disease, Parkinson's disease, stroke and other diseases, with broad application prospects.
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